Cancer mortality in a cohort of male German iron foundry workers
Identifieur interne : 000898 ( Main/Exploration ); précédent : 000897; suivant : 000899Cancer mortality in a cohort of male German iron foundry workers
Auteurs : Karl Einrich Adzersen [Allemagne] ; Nikolaus Becker [Allemagne] ; Karen Steindorf [Allemagne] ; Rainer Frentzel Eyme [Allemagne]Source :
- American Journal of Industrial Medicine [ 0271-3586 ] ; 2003-03.
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Abstract
Background: Observations of an increased incidence of cancers of the upper aero‐digestive tract (pharynx, esophagus, larynx, lung) among workers of local German foundries gave rise to concern about a potentially elevated occupational risk of those cancer sites. The purpose of the study was to examine whether occupational exposure in iron foundries increases the risk of cancer. Methods: A historical cohort study of 17,708 male German production workers in 37 iron foundries who were first employed in 1950–1985 with a minimum employment period of 1 year was initiated. Employment and occupational histories were collected. Mortality was compared with that of the German general population during 1950–1993 using a new method for computing the SMR when not all causes of death are available (called SMR*). Results: Mortality from all causes was elevated to SMR = 115.4 (95% confidence interval (CI) = 111.9–119.1), as was for total cancer (SMR* = 123.8, CI = 102.1–152.6), especially cancers of the lung (SMR* = 163.9, CI = 123.9–223.0) and liver (SMR* = 322.5, CI = 149.5–844.8), and diseases of the respiratory system (SMR* = 147.6, CI = 100.4–221.5). Non‐significant elevations of mortality were also found for cancers of the mouth and pharynx (SMR* = 153.5, CI = 82.3–359.8) and larynx (SMR* = 173.1, CI = 85.5–550.5). Mortality from various causes of death was higher among workers with shorter exposure periods than among long‐term employees. The elevated mortality persisted for years and decades after termination of employment. Conclusions: The results provide further evidence for an increased risk of lung cancer and possibly other cancers of the upper aero‐digestive tract among foundry workers. Special attention should be paid to the strongly increased mortality from liver cancer and the mortality pattern among employees having terminated work. Am. J. Ind. Med. 43:295–305, 2003. © 2003 Wiley‐Liss, Inc.
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DOI: 10.1002/ajim.10187
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J. Ind. Med.</title><idno type="ISSN">0271-3586</idno><idno type="eISSN">1097-0274</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-03">2003-03</date><biblScope unit="volume">43</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="295">295</biblScope><biblScope unit="page" to="305">305</biblScope></imprint><idno type="ISSN">0271-3586</idno></series><idno type="istex">266DD4AE60847656A4B8D1A09E44A3AF1EC871FA</idno><idno type="DOI">10.1002/ajim.10187</idno><idno type="ArticleID">AJIM10187</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0271-3586</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>cancer</term><term>cohort study</term><term>epidemiology</term><term>iron foundry</term><term>larynx</term><term>liver</term><term>lung</term><term>missing death certificates</term><term>mortality</term><term>mouth</term><term>occupation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Observations of an increased incidence of cancers of the upper aero‐digestive tract (pharynx, esophagus, larynx, lung) among workers of local German foundries gave rise to concern about a potentially elevated occupational risk of those cancer sites. The purpose of the study was to examine whether occupational exposure in iron foundries increases the risk of cancer. Methods: A historical cohort study of 17,708 male German production workers in 37 iron foundries who were first employed in 1950–1985 with a minimum employment period of 1 year was initiated. Employment and occupational histories were collected. Mortality was compared with that of the German general population during 1950–1993 using a new method for computing the SMR when not all causes of death are available (called SMR*). Results: Mortality from all causes was elevated to SMR = 115.4 (95% confidence interval (CI) = 111.9–119.1), as was for total cancer (SMR* = 123.8, CI = 102.1–152.6), especially cancers of the lung (SMR* = 163.9, CI = 123.9–223.0) and liver (SMR* = 322.5, CI = 149.5–844.8), and diseases of the respiratory system (SMR* = 147.6, CI = 100.4–221.5). Non‐significant elevations of mortality were also found for cancers of the mouth and pharynx (SMR* = 153.5, CI = 82.3–359.8) and larynx (SMR* = 173.1, CI = 85.5–550.5). Mortality from various causes of death was higher among workers with shorter exposure periods than among long‐term employees. The elevated mortality persisted for years and decades after termination of employment. Conclusions: The results provide further evidence for an increased risk of lung cancer and possibly other cancers of the upper aero‐digestive tract among foundry workers. Special attention should be paid to the strongly increased mortality from liver cancer and the mortality pattern among employees having terminated work. Am. J. Ind. Med. 43:295–305, 2003. © 2003 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>Brême (Land)</li><li>District de Karlsruhe</li></region><settlement><li>Brême</li><li>Heidelberg</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Adzersen, Karl Einrich" sort="Adzersen, Karl Einrich" uniqKey="Adzersen K" first="Karl Einrich" last="Adzersen">Karl Einrich Adzersen</name></region><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name><name sortKey="Frentzel Eyme, Rainer" sort="Frentzel Eyme, Rainer" uniqKey="Frentzel Eyme R" first="Rainer" last="Frentzel Eyme">Rainer Frentzel Eyme</name><name sortKey="Steindorf, Karen" sort="Steindorf, Karen" uniqKey="Steindorf K" first="Karen" last="Steindorf">Karen Steindorf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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